Among completed trials, 5113 (3.8%) were sponsored by the NIH or a US government agency, 48 668 (36.0%) by industry, and 81 363 (60.2%) by other sources. Results A total of 245 999 clinical trials (interventional studies) were started between 20, of which 135 144 (54.9%) were completed. Main Outcomes and Measures registration fields, including overall status, phase, intervention, number of sites, use of masking and randomization, sample size, and time to study completion by start year and lead sponsor (organization that provided funding or support for a clinical study). A static version of the Clinical Trials Transformation Initiative Aggregate Analysis of database was downloaded on January 1, 2020, for analysis. The trials were grouped by lead sponsor: National Institutes of Health (NIH) and other US government agencies, industry, and other sources (foundations, universities, hospitals, clinics, and others). Objective To assess trends in clinical trials registered in over time and by sponsor type.ĭesign, Setting, and Participants This cross-sectional study included clinical trials (interventional studies) registered in from January 1, 2000, through December 31, 2019. Little is known about the characteristics and trends in clinical trials over time and how they differ by sponsor type. Since its launch in 2000, more than 345 000 trials have been registered. Importance is a valuable resource that can be used to trace the state and nature of trials. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment. Clinical Implications of Basic Neuroscience.
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